|N-(3-三氟甲基苯基)-2-氨基苯甲酸丁酯|CsnPharm

CAS No.: 67330-25-0

Butyl 2-[[3-(Trifluoromethyl)phenyl]amino]benzoate/氟灭酸丁酯 Catalog No. CSN12172

Synonyms: Flufenamic acid butyl ester;Butyl flufenamate;EC 614-050-1

Ufenamate is a COX inhibitor, used as a topical analgesic.

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技术信息

生物活性

描述Ufenamate is an anthranilic acid-based anti-inflammatory drug developed for skin diseases, such as acute and chronic eczema, contact dermatitis, diaper dermatitis, miliaria and atopic dermatitis. Ufenamate is highly lipophilic with an octanol/water partition coefficient (log P) of 6.7. It is freely soluble in oil and is poorly soluble in water. Moreover, Ufenamate is used in the form of ointments or creams^[3]. The skin penetration amounts of ufenamate from liquid oils were significantly higher than those from WP (white petrolatum); the amounts of ufenamate were in the order WP[4].
参考文献

[1] Iino H, Fujii M, et al. Influence of Characteristics of Oily Vehicle on Skin Penetration of Ufenamate. Biol Pharm Bull. 2017;40(2):220-226.
[2] Iino H, Fujii M, et al. Penetration of Ufenamate into Intact, Stripped, or Delipidized Skin Using Different Vehicles. Biol Pharm Bull. 2015;38(10):1645-8.
[3] Penetration of Ufenamate Into Intact, Stripped, or Delipidized Skin Using Different Vehicles
[4] Influence of Characteristics of Oily Vehicle on Skin Penetration of Ufenamate

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.9644 mL
- 14.8220 mL
- 29.6440 mL
- 5 mM
- 0.5929 mL
- 2.9644 mL
- 5.9288 mL
- 10 mM
- 0.2964 mL
- 1.4822 mL
- 2.9644 mL

技术信息

CAS号

67330-25-0

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C18H18F3NO2

运输

蓝冰

分子量

337.34

别名

Flufenamic acid butyl ester;Butyl flufenamate;EC 614-050-1;HF-264;氟芬那酸丁酯

溶解度

DMSO	43.0 mg/mL (127.5 mM)

动物实验配方

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Butyl 2-[[3-(Trifluoromethyl)phenyl]amino]benzoate/氟灭酸丁酯 Catalog No. CSN12172

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